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目的探讨PPARγ2基因Pro12Ala、C1431T多态性与哈萨克族代谢综合征(MS)关系。方法应用基质辅助激光解析电离时间飞行质谱技术检测245例MS患者和244名对照者PPARγ2基因Pro12Ala、C1431T的基因型。结果与对照组比较,MS组Pro12Ala位点PP基因型和P等位基因频率差异均无统计学意义(P>0.05);MS组C1431T位点CC基因型和C等位基因频率分别为78.8%和87.6%,均高于对照组的68.4%、83.0%(P<0.05);多因素logistic回归分析显示,C1431T位点CC基因型是MS的危险因素(OR=2.043);不同因素间交互作用结果显示,饮酒者携带C1431T位点CC基因型是不饮酒者携带CT/TT基因型患病风险的2.788倍。结论 PPARγ2基因C1431T位点CC基因型、C等位基因可能是MS的遗传危险因素,CC基因型与饮酒可能存在相加交互作用。
Objective To investigate the association between PPARγ2 gene Pro12Ala and C1431T polymorphisms and Kazakh’s metabolic syndrome (MS). Methods The genotypes of PPARγ2 gene Pro12Ala and C1431T in 245 patients with MS and 244 controls were detected by matrix-assisted laser desorption / ionization time-of-flight mass spectrometry. Results Compared with the control group, there was no significant difference in the frequency of PP genotype and P allele in Pro12Ala site of MS group (P> 0.05). The frequencies of CC genotype and C allele in C1431T site of MS group were 78.8% And 87.6%, respectively, were higher than that of the control group (68.4% vs 83.0%, P <0.05). Multivariate logistic regression analysis showed that CC genotype of C1431T locus was a risk factor for MS (OR = 2.043); interaction between different factors The results showed that drinkers carrying C1431T locus CC genotype is non-drinkers carrying CT / TT genotype 2.788 times the risk. Conclusion CC genotype and C allele of C1431T locus in PPARγ2 gene may be genetic risk factors for MS. CC genotype may have an additive interaction with alcohol consumption.