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作者利用纽约市卫生局1922～75年死亡登记的伤寒慢性带菌者(共471例)的资料进行配对调查,研究慢性带菌与肝胆癌之间的联系。带菌者和对照者分成三组:有可靠死亡证明的带菌者及其对照为A组;只从伤寒登记卡获得死因的带菌者及其对照为B组;合并组包括全部带菌者和对照者。结果:追访期间死亡的471例伤寒带菌者,有103例死于肿瘤,其中28例因肝胆癌死亡。A组:包括264例带菌者和528例对照,占带菌和对照总数的56%。在恶性肿瘤中,肝胆癌引起死亡者占伤寒带菌者死亡总数的5.7%,对照组尚不到1%,差异非常显著(P<0.001)。如把带菌者中因肝胆癌死亡
Using the data from the New York City Department of Health’s 1922-75-year-old deaths registered chronic disease carriers (471 cases), the authors investigated the association between chronic carriers and hepatocellular carcinoma. The carriers and controls were divided into three groups: carriers with reliable death certificates and their controls as group A; carriers with only the cause of death from the typhoid registration card and their controls as group B; and the combined group consisted of all carriers and controls. Results: Of the 471 typhoid carriers who died during the follow-up, 103 died of tumor and 28 died of hepatobiliary cancer. Group A: comprised 264 carriers and 528 controls, accounting for 56% of the total number of carriers and controls. In malignant tumors, hepatocellular carcinoma caused 5.7% of the total number of deaths caused by typhoid carriers, while the control group was less than 1%, the difference was significant (P <0.001). Such as carriers of hepatobiliary cancer death