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目的探讨分析肺癌并发肺部感染患者痰培养分离的病原菌分布特征及耐药性特征。方法 321例肺癌并发肺部感染患者,进行痰培养并对阳性结果进行病原菌分布特征及耐药性特征的统计分析。结果痰培养中革兰阴性菌占47.15%,革兰阳性菌占12.46%,真菌占40.39%;前五位病原菌为白色念珠菌、铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌。病原菌的耐药谱分析显示,大多数革兰阴性菌和革兰阳性菌表现为多重耐药,真菌对常规抗真菌药敏感性高。结论本院近3年肺癌并发肺部感染患者的痰培养分离的病原菌以革兰阴性菌和真菌为主,细菌多重耐药情况普遍存在,真菌药敏感性较高。
Objective To investigate the distribution and drug resistance characteristics of pathogenic bacteria isolated from sputum in patients with lung cancer complicated with lung infection. Methods A total of 321 lung cancer patients with lung infection were infected with sputum and the positive results were analyzed for the distribution of pathogens and drug resistance characteristics. Results Gram-negative bacteria accounted for 47.15% in sputum culture, Gram-positive bacteria accounted for 12.46% and fungi accounted for 40.39%. The top five pathogens were Candida albicans, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae Acinetobacter baumannii. Resistance spectrum analysis of pathogenic bacteria showed that most Gram-negative and Gram-positive bacteria showed multi-drug resistance, and fungi were highly sensitive to conventional antifungal agents. Conclusions The pathogenic bacteria isolated from sputum of lung cancer patients with pulmonary infection in recent 3 years are mainly Gram-negative bacteria and fungi. The multi-drug resistance of bacteria is widespread and the susceptibility of fungi is high.