Antidepressant effect of bioactive compounds from Paecilomyces tenuipes in mice and rats

• 作 者: Hongwei Kan Liang Ming Chunru
• 机 构: AnhuiKeyLaboratoryofChineseMedicineResearchandDevelopment,DepartmentofPharmacology,ResearchCenterofE
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2010年20期
• 关键词: 生物活性化合物 细脚拟青霉 抗抑郁药 小鼠 糖皮质激素受体 大鼠 去甲肾上腺素 mRNA Paecilomyces tenuipesdepressionbeha
• 基金项目: Supported by： the Grant of Anhui Education Department No. 2004KJ194ZD, the Grant of Anhui Science ＆ Technology Department, No. 04023O48

A bioactive compound from Paecilomyces tenuipes (BCPT) has an inhibitory effect on monoamine oxidase A (MAO-A) in vitro. Researchers have thought that BCPT may be a potential antidepressant. The MAO-A suppressor moclobemide served as a control, and this s