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目的:研究不同分型的慢性前列腺炎对精液质量恶化的影响。方法:根据目前存在感染和(或)针对前列腺的自身细胞免疫反应情况,将49例慢性前列腺炎患者进行分组。健康正常的个体作为对照组。检查包括精子密度、死亡率、形态、前列腺与精囊标记物、抗精浆抗体、白细胞计数与伴随的炎症前细胞因子。结果:最严重的畸形见于无明显感染而有针对前列腺的自身细胞免疫患者。此外,在此类患者的精浆中检测到炎症前细胞因子水平显著升高。结论:伴有针对前列腺的自身细胞免疫反应的慢性前列腺炎患者的精液质量参数有重要改变,并因此而引起不育。
Objective: To study the different types of chronic prostatitis on the deterioration of semen quality. METHODS: Forty-nine patients with chronic prostatitis were grouped according to their current cellular immune response to and / or against the prostate. Healthy individuals as control group. Examination included sperm density, mortality, morphology, prostate and seminal vesicle markers, anti-seminal antibody, leukocyte count and concomitant pro-inflammatory cytokines. Results: The most severe deformities were found in autoimmune patients with prostate cancer who had no significant infection. In addition, pre-inflammatory cytokine levels were significantly elevated in seminal plasma of such patients. CONCLUSIONS: Semen quality parameters in patients with chronic prostatitis associated with prostatic cellular immune responses have important changes that lead to infertility.