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目的：探讨口服维生素D联合维生素C、乳酸杆菌制剂阴道用药治疗妊娠期细菌性阴道病的临床疗效。方法：妊娠期细菌性阴道病患者130例随机分两组，对照组65例口服维生素C、乳酸杆菌制剂阴道用药治疗，观察组65例口服维生素D联合维生素C、乳酸杆菌制剂阴道用药治疗。结果：观察组总有效率高于对照组。停药1月时复查，观察组阴道PH值、白带异常率、BV检测阳性率低于对照组，血清维生素D、症状改善率高于对照组。观察组胎膜早破发生率、产褥感染发生率、早产发生率、新生儿低体重发生率、新生儿感染发生率低于对照组，（P＜0.05）。结论：口服维生素D联合维生素C、乳酸杆菌制剂阴道用药治疗妊娠期细菌性阴道病的疗效显著。“,”Objective To investigate clinical effect of oral vitamin D combined with vitamin C, lactobacillus vaginal medication in treatment of gestational bacterial vaginal disease. Methods: 130 patients with gestational bacterial vaginal disease were randomly divided into two groups. 65 patients treated oral vitamin C; lactobacillus vaginal medication as control group. 65 patients treated oral vitamin D combined with vitamin C; lactobacillus vaginal medication as observation group. Results: Total efficiency in observation group was higher than control group. As reexamination after stopping drug 1 month, vaginal pH, leucorrhea abnormal rate, positive rate of BV detection in observation group were lower than control group, while serum vitamin D, symptom improvement rate in observation group were higher than control group. Incidence of membranes premature rupture, puerperal infection, premature birth, low birth weight rate, neonatal infection in observation group were lower than control group. (P<0.05).Conclusion Effect of oral vitamin D combined with vitamin C, lactobacillus vaginal medication in treatment of gestational bacterial vaginal disease is significant.