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目的探讨老年心力衰竭患者治疗前后血浆脑钠肽(BNP)、C-反应蛋白(CRP)水平动态变化及其意义。方法心力衰竭组为63例确诊的年龄超过60岁的心力衰竭患者,对照组为42例正常健康、年龄超过60岁人群42例。心力衰竭组在治疗前及治疗1周后测定血浆BNP、CRP浓度。结果心力衰竭各组BNP、CRP均较对照组显著增高,BNP和CRP随着心功能分级的增加而显著增加;心力衰竭组患者治疗前BNP、CRP水平与对照组比较差异有统计学意义,心力衰竭组各级别患者治疗前血浆BNP、CRP水平差异有统计学意义,心力衰竭组患者在治疗前后血浆BNP、CRP水平差异有统计学意义。结论对老年心力衰竭患者,常规检测血浆BNP、CRP浓度是诊断和评价疗效的可靠指标。
Objective To investigate the dynamic changes of plasma brain natriuretic peptide (BNP) and C-reactive protein (CRP) before and after treatment in elderly patients with heart failure. Methods 63 cases of heart failure patients with heart failure over 60 years of age were diagnosed as heart failure patients and 42 healthy controls and 42 years old patients over 60 years old as the control group. Heart failure group before treatment and after 1 week of treatment plasma BNP and CRP concentrations were measured. Results The levels of BNP and CRP in each group were significantly higher than those in control group. BNP and CRP were significantly increased with the increase of cardiac function. The levels of BNP and CRP in heart failure patients before treatment were significantly different from those in control group. Plasma BNP and CRP levels in all levels of patients in the failure group were significantly different from those in the control group. There was significant difference in plasma BNP and CRP before and after treatment in patients with heart failure. Conclusion In elderly patients with heart failure, routine examination of plasma BNP and CRP concentrations is a reliable indicator for the diagnosis and evaluation of curative effect.