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[目的]检测凋亡抑制蛋白Livin在人肾细胞癌组织中的表达,并分析其与预后的关系。[方法]采用Western Blot法检测7例正常肾组织及48例肾细胞癌标本中Livin蛋白的表达情况。[结果]Livin在正常肾组织中无表达,在肿瘤组织中阳性表达率为58.3%。Livin蛋白在不同性别、年龄、分期及分级中表达差异无统计学意义(P>0.05)。平均随访26.4个月,48例患者中有13例出现复发,复发率为27.1%。Livin表达阳性组和阴性组3年无瘤生存率分别为47.2%和71.3%,两者差异有统计学意义(P=0.02)。[结论]Livin在正常肾组织中不表达,在肾癌组织中高表达。Livin的表达与肾细胞癌分期无关,与肿瘤复发密切相关。
[Objective] To detect the expression of Livin in human renal cell carcinoma and to analyze its relationship with prognosis. [Method] Western Blot method was used to detect the expression of Livin protein in 7 normal kidney tissues and 48 renal cell carcinoma specimens. [Results] Livin was not expressed in normal kidney tissues, and the positive rate of Livin in tumor tissues was 58.3%. The expression of Livin protein in different sex, age, stage and grade had no statistical significance (P> 0.05). With an average follow-up of 26.4 months, 13 of 48 patients developed recurrence with a recurrence rate of 27.1%. The 3-year disease-free survival rates of positive Livin expression group and negative group were 47.2% and 71.3%, respectively, with significant difference (P = 0.02). [Conclusion] Livin is not expressed in normal renal tissues and highly expressed in renal carcinoma tissues. The expression of Livin has nothing to do with the stage of renal cell carcinoma, and is closely related to tumor recurrence.