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目的 探讨亚急性炎性脱髓鞘性多发性神经根神经病 (SIDP)的临床和病理特点。方法 对 7例SIDP患者临床资料和腓肠神经活检所见进行分析。结果 患者呈亚急性起病 ,达到高峰时间均在 4周～ 2个月 ;运动障碍较感觉障碍明显 ,上升性呼吸肌麻痹很少发生 ,对激素治疗有效且无复发。 3例腓肠神经活检 ,病理显示 :以脱髓鞘为主要表现 ,伴有单核细胞浸润 ,胶原纤维增生 ,但无洋葱样肥大神经改变。结论 SIDP不论临床表现还是病理特点都不同于急、慢性炎性脱髓鞘性多发性神经根神经病 (AIDP、CIDP) ,而是介于两者之间
Objective To investigate the clinical and pathological features of subacute inflammatory demyelinating polyneuropathy (SIDP). Methods The clinical data of 7 patients with SIDP and the findings of sural nerve biopsy were analyzed. Results Patients were subacute onset, reached the peak time of 4 weeks to 2 months; dyskinesia than sensory disturbances, ascending respiratory muscle paralysis rarely occurs, effective and no recurrence of hormone therapy. Three cases of sural nerve biopsy, the pathology showed: demyelination as the main manifestation, accompanied by mononuclear cell infiltration, collagen fibrosis, but no change of onion-like hypertrophy. Conclusions SIDP is different from acute and chronic inflammatory demyelinating polyneuropathies (AIDP, CIDP) both in clinical and pathological features, but between the two