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目的探析北五味子单方提取物在抗结核治疗中对肝功能的保护作用,为临床制定预防抗结核化疗所致的肝损伤方案提供参考。方法选择不同治疗期间的388例结核治疗患者,分为治疗组和对照组,治疗组予北五味子单方提取物联合抗结核药方案(2HRZE(S)/4HRE)治疗,对照组抗结核方案与治疗组相同,并予口服葡醛内酯片护肝。治疗结束后,比较2组患者体征、肝功能情况以及临床症状。结果治疗组肝损害轻度发生率要显著高于对照组,中度与重度发生率明显低于对照组,两组比较差异有统计学意义(均P<0.05);肝损伤发生率、发生时间及痊愈率、治疗死亡率、肝硬化、肝功能衰竭以及停止抗结核治疗率等指标两组比较差异有统计学意义(均P<0.05);结论在抗结核药物治疗中,联合北五味子单方提取物可有效保护肝功能,预防药物所致肝损伤,不良反应小,可作为优质方案在临床应用。
Objective To investigate the protective effect of unilateral extract of Schisandra chinensis on liver function in anti-tuberculosis treatment and to provide a reference for the clinical development of a program to prevent liver injury caused by anti-tuberculosis chemotherapy. Methods A total of 388 tuberculosis patients were selected during the treatment period. The treatment group was divided into treatment group and control group. The treatment group was treated with 2HRZE (S) / 4HRE and the combination of anti-tuberculosis drug (2HRZE (S) / 4HRE) The same group, and oral glucurolaide tablets Liver. After the treatment, the signs, liver function and clinical symptoms of the two groups were compared. Results The mild incidence of liver damage in the treatment group was significantly higher than that in the control group, moderate and severe incidence was significantly lower than the control group, the difference between the two groups was statistically significant (all P <0.05); liver injury incidence, time And cure rate, treatment mortality, cirrhosis, liver failure and the rate of stopping antituberculosis treatment were significantly different between the two groups (all P <0.05) .Conclusion In the anti-TB drug treatment, combined with Schisandra sp. Materials can effectively protect the liver function, prevention of drug-induced liver injury, adverse reactions, can be used as a quality program in clinical applications.