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目的 探讨血清前列腺特异性抗原 (PSA)水平中度升高时 (4.0～ 10 .0ng/ml) ,游离PSA(fPSA)与总PSA(tPSA)比值 (f/tPSA)和结合PSA(cPSA)在前列腺癌 (PCa)诊断中的作用及区分PCa和前列腺增生(BPH)的能力。方法 采用酶联免疫荧光分析方法 ,在 2 8例PCa患者和 33例BPH患者中 ,选择tPSA值在 4 .0～10 .0ng/ml范围的血清标本 ,分别检测、计算fPSA和cPSA ,分析tPSA、f/tPSA、cPSA的临床意义。结果 当血清tP SA在 4 .0～ 10 .0ng/ml时 ,f/tPSA比值在PCa和BPH两组患者中有非常显著性差异 (P <0 .0 1) ,明显地提高了PCa诊断的特异性 ;而cPSA在PCa和BPH两组患者中无显著差别 (P >0 .0 5 )。结论 当血清tPSA在 4 .0～ 10 .0ng/ml时 ,在区分、诊断PCa和BPH上 ,f/tPSA比值明显优于tPSA ,而cPSA并不优于tPSA。
Objective To investigate the relationship between the serum PSA level and the PSA / cPSA ratio in moderately elevated (4.0-10.0ng / ml), free PSA (fPSA) to total PSA (tPSA) The role of prostate cancer (PCa) in diagnosis and the ability to differentiate between PCa and benign prostatic hyperplasia (BPH). Methods Enzyme-linked immunosorbent assay (FACS) was used to detect fPSA and cPSA in 28 patients with PCa and 33 patients with BPH. Serum samples with tPSA values ranging from 4.0 to 10.0 ng / ml were used for the analysis of tPSA , F / tPSA, cPSA clinical significance. Results When the serum tP SA was between 4.0 and 10.0 ng / ml, the f / tPSA ratio in patients with PCa and BPH had a significant difference (P <0.01), which significantly increased the risk of PCa diagnosis Specificity; and cPSA in PCa and BPH patients no significant difference (P> 0.05). Conclusions When serum tPSA is between 4.0-10.0ng / ml, f / tPSA ratio is superior to tPSA in differentiating PCa from BPH, but cPSA is not superior to tPSA.