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目的:了解丽水地区人乳头瘤病毒(HPV)基因型在宫颈癌及癌前病变中的分布。方法:采用HPV分型基因芯片检测系统对68例宫颈癌、62例宫颈上皮内瘤变患者进行HPV基因分型检测,以100例子宫颈炎患者的HPV基因型别作为参照。结果:子宫颈炎、宫颈上皮内瘤变和宫颈癌中HPV检出率分别为75.0%、84.0%和95.5%,其间差异比有显著性。在宫颈癌及癌前病变中,主要基因型分别为HPV16,58,53,52,68和18。结论:丽水市及周边地区宫颈癌及宫颈上皮内瘤变中HPV感染率很高,以16、58、53、52和68型最为常见。
Objective: To understand the distribution of human papillomavirus (HPV) genotypes in cervical cancer and precancerous lesions in Lishui area. Methods: HPV genotypes were detected in 68 cases of cervical cancer and 62 cases of cervical intraepithelial neoplasia by HPV genotyping system. The genotypes of HPV in 100 cases of cervicitis were used as reference. Results: The positive rates of HPV in cervicitis, cervical intraepithelial neoplasia and cervical cancer were 75.0%, 84.0% and 95.5%, respectively, with a significant difference between them. In cervical cancer and precancerous lesions, the main genotypes were HPV16, 58,53,52,68 and 18 respectively. Conclusion: The prevalence of HPV infection in cervical cancer and cervical intraepithelial neoplasia in Lishui City and the surrounding areas is very high, most commonly 16, 58, 53, 52 and 68.