论文部分内容阅读
目的 探讨皮肌炎的临床特点。方法 对 114例皮肌炎患者进行临床分析。结果 该病可见于各个年龄组 ,女性略多于男性 ,80 %患者以下肢无力症状为首发。通过对 2 6例患者肌肉活检 ,阳性率达 10 0 %。对乳酸脱氢酶 ( L DH )、肌酸激酶 ( CK )、丙氨酸转氨酶 ( AL T)、天冬氨酸转氨酶 ( AST)等肌肉酶学的检查 ,其阳性率分别为 97%、93%、5 7%、5 4%。肌电图检查的阳性率为 95 .6 % ,主要表现为肌源性损害。15 %患者有肺部炎症表现 ,4%患者合并肿瘤 ,年龄均在 40岁以上。 15例死亡 ,死因分别为感染、肿瘤及心力衰竭。结论 首发症状不典型 ,对于不明原因的皮损患者 ,应注意有无四肢近端无痛性肌无力的表现 ,结合肌肉酶学、肌电图及肌肉活检等检查 ,早期诊断并不困难。对于 40岁以上的患者 ,应作全面的检查 ,以发现早期隐匿的恶性肿瘤
Objective To explore the clinical features of dermatomyositis. Methods 114 cases of dermatomyositis patients were analyzed. Results The disease can be seen in all age groups, slightly more women than men, 80% of patients with leg weakness as the first episode. Through the 26 patients with muscle biopsy, the positive rate of 100%. The positive rates of muscle enzymes such as L DH, CK, ALT and AST were 97%, 93% %, 57%, 54%. The positive rate of EMG examination was 95.6%, mainly manifested as myogenic damage. 15% of patients had lung inflammation, 4% of patients with tumor, aged over 40 years of age. Fifteen patients died of infection, cancer and heart failure. Conclusions The first symptom is not typical. For patients with unexplained skin lesions, attention should be paid to the presence or absence of painless muscle weakness in the proximal extremities. Combined with the tests of muscle enzymology, EMG and muscle biopsy, early diagnosis is not difficult. For patients over the age of 40, should be fully inspected to detect early occult malignancy