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目的以人胃癌细胞株裸鼠腹腔种植模型，比较术后早期和延期腹腔内化疗对胃癌细胞腹腔种植生长的影响程度。方法３４只雄性裸鼠腹腔内接种ＭＫＮ┐４５细胞（３×１０６细胞数／只）后，随机分成对照组和４个不同剂量、不同时间表阿霉素腹腔内化疗组。结果对照组裸鼠致瘤率为６／６（１００％），０．４ｍｇ·ｋｇ－１·ｄ－１和０．８ｍｇ·ｋｇ－１·ｄ－１表阿霉素早期腹腔内化疗（接种后１～３天）的致瘤率分别为２／７和１／７；前两种不同剂量表阿霉素的延期腹腔内化疗（接种后５～７天）的致瘤率均为６／７。早期腹腔内化疗的抑瘤作用明显高于延期腹腔内化疗（Ｐ＜０．０５）。结论在预防胃癌术后腹腔内种植复发时，术后早期腹腔内化疗优于术后延期腹腔内化疗。
Objective To compare the effect of early and delayed intraperitoneal chemotherapy on the growth of gastric cancer cells in the abdominal cavity of human gastric cancer cell line nude mice. Methods Thirty-four male nude mice were intraperitoneally inoculated with MKN┐45 cells (3×106 cells/body) and randomly divided into control group and four different doses of different schedules of adriamycin intraperitoneal chemotherapy group. Results The tumorigenic rate of the control group was 6/6 (100%), 0.4 mg·kg -1·d -1 and 0.8 mg·kg -1·d -1 epirubicin early intraperitoneal chemotherapy (inoculation) The tumorigenesis rates were 1/7 and 1/7 after 1 to 3 days, respectively; the oncogenic rates of delayed intraperitoneal chemotherapy of the first two different doses of epirubicin (5 to 7 days after inoculation) were all 6/ 7. The inhibitory effect of early intraperitoneal chemotherapy was significantly higher than that of delayed intraperitoneal chemotherapy (P<0.05). Conclusion In the prevention of postoperative recurrence of gastric cancer after intra-abdominal implantation, postoperative intraperitoneal chemotherapy is superior to postoperative delayed intraperitoneal chemotherapy.