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目的研究氧代赖氨酸（Ｌ－４－ｏｘａｌｙｓｉｎｅ，ＯＸＬ）对小鼠实验性肝癌的治疗作用。方法采用小鼠肝癌－２２（Ｈ－２２）腹水瘤皮下移植模型。结果ＯＸＬ１５０ｍｇ／ｋｇ和３００ｍｇ／ｋｇ腹腔注射共７天，对小鼠Ｈ－２２肝癌的生长有明显抑制作用，抑制率分别为３８．７％和６８．８％。ＯＸＬ３００ｍｇ／ｋｇ口服或肌肉注射共７天，也有明显的抗癌活性。同时给小鼠腹腔注射ＯＸＬ１５０ｍｇ／ｋｇ及氟尿嘧啶（５－ＦＵ）１２．５ｍｇ／ｋｇ共７天，对Ｈ－２２实体瘤生长的抑制率由单用ＯＸＬ时的３８．７％和单用５－ＦＵ时的３０．１％提高到合用时的７１．１％。ＯＸＬ３００ｍｇ／ｋｇ以不同途径给药对荷肝癌小鼠体重、免疫器官重量以及肾脏重量无明显影响；给予４００ｍｇ／ｋｇ时，体重和免疫器官重量明显减轻，但肾脏重量无明显改变。结论ＯＸＬ在体内对小鼠肝癌实体瘤的生长有一定抑制作用，不同给药途径抑瘤率相似，且与５－ＦＵ合用有协同抗瘤结果
Objective To study the therapeutic effect of oxo-lysine (OXL) on experimental liver cancer in mice. Methods The mouse liver cancer-22 (H-22) ascites tumor subcutaneous transplantation model was used. Results OXL 150mg/kg and 300mg/kg intraperitoneal injection for 7 days, significantly inhibited the growth of H-22 hepatocarcinoma in mice. The inhibition rates were 38.7% and 68.8%, respectively. Oral or intramuscular injection of OXL300mg/kg for 7 days also has significant anticancer activity. At the same time, mice were injected intraperitoneally with OXL150mg/kg and fluorouracil (5-FU) 12.5mg/kg for 7 days. The inhibition rate of solid tumor growth of H-22 was 38.7% when using OXL alone and 5- 30.1% of FU increased to 71.1% at the time of use. OXL300mg/kg administered by different ways had no significant effect on body weight, immune organ weight and kidney weight of the hepatoma-bearing mice; when given 400mg/kg, body weight and immune organ weight were significantly reduced, but no significant changes in kidney weight. Conclusion OXL has a certain inhibitory effect on the growth of solid tumors of mouse hepatocellular carcinoma in vivo. The rate of tumor inhibition is similar for different routes of administration, and there is a synergistic antitumor effect with 5-FU.