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侧脑室前角和导水管埋有导管的雄性灰兔39只,随机分为供液组和受液组。供液兔经热锻炼适应后在高温和常温下的脑室灌流液,给受液兔进行脑室灌流。结果发现:能使受液兔常温下灌流60min时的肛温降低,分别比灌流人工脑脊液对照低0.5℃和0.4℃;使高温下灌流60min时的肛温上升减慢,分别较对照低0.3℃和0.33℃,与供液兔自身热锻炼适应后所能提高的耐热能力相近。而未热锻炼和初次热应激供液兔的脑室灌流液,对受液兔的肛温无明显影响。这表明热适应后的脑室液中,出现了能诱发未热适应兔产生相似热适应效应的、降低肛温的神经活性物质——致热适应因子(heat acclimato-inducing factor)。从而揭示了在脑中枢的特定部位,存在促进热适应形成的神经化学机制;并讨论了该神经活性物质可能是一种多次。
A total of 39 male gray rabbits with anterior horn of lateral ventricle and catheters buried in the aqueduct were randomly divided into donor group and recipient group. After the rabbits were subjected to hot exercise, the rabbits were intravenously infused with ventricular fluid at high temperature and room temperature. The results showed that the rectal temperature of the rabbits perfussed at room temperature for 60 min decreased by 0.5 ℃ and 0.4 ℃, respectively, compared with that of the control group. The rectal temperature increased slowly at 60 ℃ for 60 min, which was 0.3 ℃ lower than that of the control And 0.33 ℃, which is similar to the heat-resistant ability that can be improved by the rabbit’s own hot exercise adaptation. Without hot exercise and initial heat stress rabbit intraventricular fluid, the rectal temperature of the rabbit had no significant effect. This indicates that there is a heat acclimato-inducing factor that reduces the rectal temperature in the warm-adapted ventricular fluid and induces a similar thermal adaptation effect in the un-adapted rabbit. Thus, it is revealed that there is a neurochemical mechanism that promotes the formation of heat adaptation in a specific part of the brain center. It is also discussed that the neuroactive substance may be a multiple of times.