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目的:了解缺血性卒中住院患者一、二级预防抗栓药物的应用现状,为该类患者二级预防合理使用抗栓药物提供参考。方法:研究对象为急性脑梗死住院患者,对其出院带药(方案)进行用药指导,同时调查其入院之前卒中一、二级预防抗栓药物的应用状况。结果:入选患者共178例,其中第1次发作106例,使用抗栓药物者36例(一级预防抗栓药物使用率34%),第2次及以上发作72例,使用抗血栓药物者56例(二级预防78%);在92例使用抗栓药物进行卒中一、二级预防的患者中,以规范的剂量和频次服用阿司匹林和氯吡格雷者56例(61%);长期服药者46例(坚持服药率50%)。结论:缺血性卒中患者一、二级预防抗栓药物的应用现状不容乐观,存在其应用比例较少、剂量不足、服药间断现象。临床医生、药师应对缺血性卒中患者一、二级预防抗栓药物的合理使用应给予正确、全面指导,以提高用药的依从性。
Objective: To understand the application status of primary and secondary prevention antithrombotic drugs in hospitalized patients with ischemic stroke, and to provide a reference for the rational use of antithrombotic drugs in secondary prevention of these patients. Methods: The subjects of the study were hospitalized patients with acute cerebral infarction, medication guidance for their discharge (program), and to investigate the application of antithrombotic drugs before and after admission to the primary and secondary prevention of stroke. Results: A total of 178 patients were enrolled, of which 106 cases were the first attack, 36 cases were treated with antithrombotic drugs (primary prevention of antithrombotic drug use rate was 34%), the second and the above seizures were 72 cases and those with antithrombotic drugs 56 patients (61%) took aspirin and clopidogrel at standard dosage and frequency in 92 patients with primary or secondary prevention of stroke using antithrombotic drugs. Long-term medication 46 cases (adhere to the medication rate of 50%). Conclusion: The status of application of primary and secondary prevention antithrombotic drugs in patients with ischemic stroke is not optimistic. There are less applications, insufficient doses and intermittent medication. Clinicians and pharmacists should be given proper and comprehensive guidance on the rational use of primary and secondary prevention antithrombotic drugs in patients with ischemic stroke to improve the compliance of medication.