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目的研究苦参凝胶单次给药对大鼠的急性毒性。方法将20只雌性SD大鼠随机分为苦参凝胶组和基质组(每组10只),分别予苦参凝胶和基质阴道给药,每天2次,共给药1天。连续观察给药14天内大鼠一般情况、体质量、摄食量、体温等变化情况,及第15天阴道等组织器官的大体解剖结构。结果两组大鼠一般情况未见异常;两组大鼠体重、摄食量、体温等比较,差异均无统计学意义(P>0.05);两组大鼠解剖后肉眼观察均未发现任何异常。结论苦参凝胶阴道用药安全性高。
Objective To study the acute toxicity of Sophora flavescens Gel single administration to rats. Methods Twenty female Sprague-Dawley rats were randomly divided into two groups: Sophora albus group and matrine group (10 in each group), which were treated with matrine gel and vaginal administration twice a day for 1 day. The changes of general condition, body weight, food intake, body temperature and other anatomical structures of the vagina and other tissues and organs on day 15 were observed continuously for 14 days. Results There were no abnormalities in the two groups. There was no significant difference in body weight, food intake and body temperature between the two groups (P> 0.05). No abnormalities were found in macroscopic observation of the two groups. Conclusion Sophora gel gel vaginal medication safety.