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目的探索冠脉病变程度与糖代谢紊乱及β细胞功能的关系,为血糖异常患者预防心血管并发症提供依据。方法对183例接受了冠脉造影(CAG)的患者行口服糖耐量试验(OGTT)及胰岛素释放试验(IRT),分析冠脉病变程度与血糖及β细胞功能的相关性。结果在FBG<5.6 mmol/L的糖调节受损(IGR)组中[包括糖耐量减低(IGT)和糖尿病],2hBG与冠脉病变程度呈正相关(r=0.316,P<0.01),β细胞功能指数(HOMA-β)与冠脉病变程度呈负相关(r=0.566,P<0.01);而在FBG>5.6mmol/I组中,2hBG、HOMAβ与冠脉病变程度不相关(2hBG:r=0.017,P>0.05;HOMA-β:r=0.280,P>0.05)。结论在FBG正常的IGR中,2hBG及β细胞功能损害与冠脉病变程度具有显著相关,而在FBG异常患者中三者的关联减弱。
Objective To explore the relationship between the degree of coronary artery disease and glucose metabolism disorder and β-cell function, and to provide basis for prevention of cardiovascular complications in patients with abnormal blood glucose. Methods Oral glucose tolerance test (OGTT) and insulin release test (IRT) were performed in 183 patients with coronary artery angiography (CAG). The correlation between coronary artery lesion and blood glucose and β-cell function was analyzed. Results The 2hBG was positively correlated with the degree of coronary artery lesion (r = 0.316, P <0.01) in the group of impaired glucose regulation (IGGR) <5.6 mmol / L [including impaired glucose tolerance (IGT) and diabetes mellitus) The level of HOMA-β was negatively correlated with the degree of coronary artery lesion (r = 0.566, P <0.01). In FBG> 5.6mmol / I group, = 0.017, P> 0.05; HOMA-β: r = 0.280, P> 0.05). Conclusions In IGR with normal FBG, the functional damage of 2-hBG and β-cells is significantly correlated with the degree of coronary artery lesion, while the association among the three abnormalities in FBG is weakened.