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本文采用高效液相色谱技术(HPLC)测定了三个海拔高度大鼠血清中三磷酸腺苷(ATP)的含量。于海拔4900m地区大鼠血清中ATP的含量明显低于海拔2260m及320m地区(P<0.001及<0.01);后两者间虽存有差别,但无显著性意义(P<0.05)。表明在重度缺氧条件下,动物血清中ATP含量明显减少。ATP是直接能为机体所利用的高能化合物,机体对缺氧适应的关键是保持高能化合物于正常水平。本文对高原缺氧条件下能量代谢的动态变化及其生理、病理学基础进行了讨论。
In this paper, high-performance liquid chromatography (HPLC) was used to determine the content of ATP in serum of three altitudes rats. The content of ATP in rat serum at 4900m altitude was significantly lower than that at 2260m and 320m altitude (P <0.001 and <0.01). There was no significant difference between the two groups (P <0.05). The results showed that under the condition of severe hypoxia, the content of ATP in serum decreased obviously. ATP is a high-energy compound that can be directly utilized by the body. The key to adapt to the hypoxia is to maintain high-energy compounds at normal levels. This paper discusses the dynamic changes of energy metabolism and its physiological and pathological basis under anaerobic plateau conditions.