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固体分散体是指将药物高度分散于惰性载体中,形成的一种以固体形式存在的分散体系.固体分散的最早出现于丹麦Ferrossam制药公司,于1933年首次应用脂油性的氢化植物油为基质,以稀乙醇为冷却剂制备维生素AD滴丸.1956年Bjornssion等开始用水溶性的聚乙二醇(PEG)4000为基质,植物油为冷却剂制备苯巴比妥滴丸.但大多数学者仍认为固体分散技术是60年代由Sekiguchi(1961年)制备磺胺噻唑(ST)-尿素固体分散物开始逐渐发展起来的一种新方
Solid dispersion refers to the drug is highly dispersed in an inert carrier to form a dispersion in the form of solid dispersion first appeared in the Danish Ferrossam Pharmaceutical Company, in 1933 for the first time the use of fat-based hydrogenated vegetable oil as a substrate, Dilute ethanol as a coolant to prepare vitamin AD drops pills in 1956 Bjornssion et al began to use water-soluble polyethylene glycol (PEG) 4000 as a substrate, vegetable oil as a coolant phenobarbital drop pills, but most scholars still believe that the solid Dispersion technology was developed in the 1960s by Sekiguchi (1961) for the preparation of sulfathiazole (ST) - urea solid dispersions