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目的:用Meta分析的方法综合评价HLA-B*1502等位基因与亚裔人群芳香族抗癫痫药物严重不良反应的关联性。方法:检索EBSCO数据库、Springer数据库、Highwire Press数据库、Medline数据库、维普数据库和清华同方数据库,根据纳入与排除标准,收集所有符合标准的病例-对照研究,应用Excel 2000和SPSS13.0软件对符合条件的研究结果进行Meta分析。结果:符合纳入标准的共4篇文献,合计包含病例组118例,健康对照组311例,经Egger’s检验未见显著发表偏倚。经综合分析:合并OR值为15.952,95%CI为9.393~27.091(P=0.000),认为HLA-B*1502等位基因是亚裔癫痫人群服用芳香族抗癫痫药物发生严重不良反应的易感基因。结论:HLA-B*1502等位基因与亚裔癫痫人群服用芳香族抗癫痫药物发生严重不良反应具有统计学关联性,为易感基因。
OBJECTIVE: To evaluate the association between the HLA-B * 1502 allele and the serious adverse reactions of aromatic antiepileptic drugs in Asian population by Meta-analysis. Methods: The EBSCO database, Springer database, Highwire Press database, Medline database, VIP database and Tsinghua Tongfang database were searched. All the eligible case-control studies were collected according to inclusion and exclusion criteria. Excel 2000 and SPSS 13.0 The results of the Meta-analysis. Results: A total of 4 articles met the inclusion criteria, including a total of 118 cases in the case group and 311 cases in the healthy control group. No significant publication bias was found by Egger’s test. According to a comprehensive analysis, the combined OR was 15.952, and the 95% CI was 9.393 ~ 27.091 (P = 0.000). It was considered that the HLA-B * 1502 allele was predisposed to serious adverse reactions in Asian epilepsy patients taking aromatic antiepileptic drugs gene. CONCLUSION: HLA-B * 1502 allele is associated with serious adverse reactions in Asian epilepsy patients taking aromatic antiepileptic drugs and is a susceptible gene.