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应用硝苯吡啶治疗心力衰竭96例,总有效率93.7%。疗效:急性左心衰见效快,全心衰、慢性右心衰见效较慢。治疗后血压、心率均有不同程度下降,心搏量及心排血量增加,外周阻力、平均动脉压下降,心功能、心肌缺血均有改善。本药未见严重不良副作用。随访33例病情稳定。硝苯吡啶通过在平滑肌兴奋-收缩耦联中对抗钙离子,从而扩张冠状动脉、外周阻力血管和小静脉,减轻心脏前后负荷,主要为后负荷。增加每搏(?)出量,减少左室舒张末期充盈容量及压力,改善心功能。另外硝苯吡啶强烈扩张周围血管,激发交感神经反射,增加心脏收缩力,使心脏血流动力学变为低阻力一高排血量,因此用于治疗心衰。
Nifedipine treatment of heart failure in 96 cases, the total effective rate was 93.7%. Efficacy: acute left heart failure quick, full heart failure, chronic right heart failure more effective. After treatment, blood pressure and heart rate were decreased to varying degrees, stroke volume and cardiac output increased, peripheral resistance, mean arterial pressure decreased, cardiac function, myocardial ischemia have improved. The drug has no serious adverse side effects. 33 cases were followed up in stable condition. Nifedipine antagonizes calcium ions in the excitatory-contractile coupling of smooth muscle to dilate the coronary arteries, peripheral resistance blood vessels and small veins and reduce the anterior and posterior cardiac load, mainly post-stress. Increase stroke volume (?) Output, reduce left ventricular end-diastolic filling capacity and pressure, improve heart function. In addition, nifedipine strongly dilates peripheral blood vessels, stimulates sympathetic reflex, increases cardiac contractility, and changes the cardiac hemodynamics to a low-drag and high-output blood volume. Therefore, nifedipine is used to treat heart failure.