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目的:探讨长期服用氢氯噻嗪(HCTZ)后肾素-血管紧张素-醛固酮系统(RAAS)活性变化与血糖(GLU)变化之间的关系。方法:选择119例高血压患者,测定基线RAAS活性和GLU水平等指标后,给予HCTZ12.5mg,qd,1年后测定RAAS活性和GLU水平,分析服用HCTZ1年后RAAS活性变化与GLU水平之间的关系。结果:服用HCTZ1年后,血清肾素活性(PRA)水平升高组与不升高组患者GLU水平下降幅度分别是(-0.26±0.26)mmol·L-1、(-1.36±0.23)mmol·L-1,差异有统计学意义(P<0.05);血清血管紧张素Ⅱ(AngⅡ)水平升高组与不升高组患者GLU水平下降幅度分别是(-0.17±0.18)mmol·L-1、(-1.07±0.21)mmol·L-1,差异有统计学意义(P<0.05)。服药后AngⅡ水平升高的患者中,GLU水平同时也升高的人数比例(40.5%)明显高于AngⅡ水平不升高患者中的相应患者比例(16.9%),差异有统计学意义(P<0.05)。校正年龄、性别、基线GLU水平等其他因素影响后,服用HCTZ1年后的血清AngⅡ水平变化与GLU水平变化独立相关。结论:服用HCTZ1年后的RAAS活性变化与GLU变化之间存在相关关系。
Objective: To investigate the relationship between the change of activity of renin-angiotensin-aldosterone system (RAAS) and the change of blood glucose (GLU) after long-term administration of hydrochlorothiazide (HCTZ). Methods: One hundred and nineteen patients with hypertension were enrolled. The baseline RAAS activity and GLU level were measured. HCTZ 12.5 mg qd was given for one year. The activity of RAAS and GLU level were measured after 1 year. The changes of RAAS activity and GLU level after 1 year HCTZ were analyzed Relationship. Results: After 1 year of taking HCTZ, the decrease of GLU level was (-0.26 ± 0.26) mmol·L-1, (-1.36 ± 0.23) mmol · (-1) in patients with elevated serum renin activity (PRA) L-1, the difference was statistically significant (P <0.05). The decrease of GLU level in patients with and without serum AngⅡ was (-0.17 ± 0.18) mmol·L-1 , (-1.07 ± 0.21) mmol·L-1, the difference was statistically significant (P <0.05). The proportion of patients with elevated levels of GLU at elevated GLU level (40.5%) was significantly higher than that of patients without elevation of AngⅡ level (16.9%, P < 0.05). After adjusting for age, gender, baseline GLU level and other factors, the changes of AngⅡ level after 1 year of taking HCTZ were independently related to the changes of GLU level. CONCLUSIONS: There is a correlation between changes in RAAS activity and changes in GLU after 1 year of HCTZ administration.