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帕金森病(Parkinson’s disease,PD)是一种常见的严重中枢退行性疾病萁主要病理特征是中脑黑质多巴胺(Dopamine,DA)能神经元变性与丢失,导致纹状体内DA含量明显下降雉体外系功能失调。PD患者出现静止性震颤、动作迟缓、肌肉僵直、异常步态等症状,并呈进行性加重。临床传统药物如Levodopa(L-DOPA)等治疗能够有效改善症状,但长期用药后会出现药效的显著下降,并且诱发异常运动等严
Parkinson’s disease (PD) is a common serious central degenerative disease. The main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain, resulting in a significant decrease of DA content in the striatum In vitro dysfunction. PD patients with rest tremor, slow motion, muscle stiffness, abnormal gait and other symptoms, and was progressive increase. Clinical conventional drugs such as Levodopa (L-DOPA) and other treatment can effectively improve the symptoms, but after long-term medication there will be a significant reduction in efficacy, and induce abnormal movement and other serious