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2013年10月~2014年8月本溪市中心医院内分泌科住院54例合并周同神经病变的老年2型糖尿病患者,观察基础降糖治疗上采用硫辛酸+前列地尔+甲钴胺治疗,观察联合治疗的临床疗效、治疗前后周围神经病变的总症状评分(TSS)等疗效指标和不良反应。治疗前后疗效比较采用配对t检验。结果:硫辛酸注射液联合治疗10 d后的TSS评分中刺痛、烧灼感、感觉减退和麻木症状评分均较治疗前明显缓解,治疗总有效率为92.3%,差异有统计学意义(P<0.01)。研究过程中仅有1例患者出现轻度皮疹,未经特殊处理自行缓解。结论:硫辛酸、前列地尔联合甲钴胺治疗老年糖尿病周围神经病变疗效确切。
From October 2013 to August 2014, 54 elderly patients with type 2 diabetes mellitus who were hospitalized with Endocrinology in Benxi Central Hospital were treated with lipoic acid plus promethazole plus mecobalamin. The clinical efficacy of combined therapy, the total symptom score (TSS) of peripheral neuropathy before and after treatment and other efficacy indicators and adverse reactions. Before and after treatment compared with paired t test. Results: The TSS score of lipoic acid injection 10 days after treatment was significantly lower than those before treatment in TSS score, the total effective rate was 92.3%, the difference was statistically significant (P < 0.01). In the course of the study, only 1 patient developed a mild rash that was relieved without special treatment. Conclusion: Lipoic acid and prostaglandin combined with mecobalamin are effective in treating diabetic peripheral neuropathy in the elderly.