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关于胃溃疡发病的机理,近年来,认为与胆汁返流、胃粘膜屏障的破坏及其慢性炎症的刺激有密切关系。此外,高级中枢神经系统的功能紊乱,饮食不调等在溃疡病发病方面也有一定关系。现将胃溃疡的药物治疗近况作一介绍。一、抑制或减少胆汁逆流 1.胃复胺(metoclopramide):为胃运动促进剂,可使胃运动功能亢进,提高胃窦收缩频率和强度,促进胃排空,减少胃酸与胃蛋白酶对溃疡的刺激;可减少胆汁返流量,阻止胆汁对胃粘膜损害;并能调整胃活动使之趋于正常,故利于溃疡的愈合。毒副作用低,偶有
On the pathogenesis of gastric ulcer in recent years, that the bile reflux, gastric mucosal barrier damage and the stimulation of chronic inflammation are closely related. In addition, advanced central nervous system dysfunction, poor diet and so on in the pathogenesis of ulcer disease also has a certain relationship. Now the status of gastric ulcer drug treatment for an introduction. First, the inhibition or reduction of bile reflux 1. Metoclopramide (metoclopramide): gastric motor accelerators, gastric motility can be hyperthyroidism, improve the frequency and intensity of gastric antrum contraction, and promote gastric emptying, reduce gastric acid and pepsin on ulcer Stimulation; can reduce the amount of bile reflux to prevent bile gastric mucosal damage; and can regulate the activity of the stomach tends to be normal, it is conducive to ulcer healing. Low side effects, occasionally