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目的回顾性分析我科近5年来70岁以上老年食管癌三维适形放疗疗效及耐受性。方法采用6 MV X射线,三维适形放疗,常规分割2 Gy/次,每天一次,每周5天。90%PTV(60~66 Gy)/(30~33 f)。结果 66例中完全缓解8例、部分缓解41例、稳定11例、进展6例,总有效率74.2%,1年生存率56.1%,2年生存率24.2%,3年生存率10.6%。主要毒性反应为放射性食管炎51例,1~2级36例,3级15例。放射性气管炎9例,放射性肺炎3例,骨髓抑制18例,心脏毒性0例。结论三维适形放疗适合70岁以上老年食管癌的治疗,且安全有效。
Objective To retrospectively analyze the efficacy and tolerability of three-dimensional conformal radiotherapy for esophageal cancer in elderly patients over 70 years in the recent 5 years. Methods 6 MV X-ray, three-dimensional conformal radiotherapy, conventional segmentation 2 Gy / time, once a day, 5 days a week. 90% PTV (60-66 Gy) / (30-33 f). Results In 66 cases, 8 cases were completely relieved, 41 cases were partially relieved, 11 cases were stable, 6 cases progressed. The total effective rate was 74.2%, the 1-year survival rate was 56.1%, the 2-year survival rate was 24.2%, and the 3-year survival rate was 10.6%. The main toxicities were radioactive esophagitis in 51 cases, grade 1 ~ 2 in 36 cases and grade 3 in 15 cases. Radiation tracheitis in 9 cases, 3 cases of radiation pneumonitis, bone marrow suppression in 18 cases, 0 cases of cardiotoxicity. Conclusion Three-dimensional conformal radiotherapy is suitable for the treatment of elderly patients with esophageal cancer over 70 years old, and is safe and effective.