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目的:探讨苍苓止泻口服液联合思密达对轮状病毒肠炎患儿肠道免疫的影响。方法:随机选取200例轮状病毒患儿,苍苓止泻口服液与思密达联合用药组100例,单纯使用思密达100例,计算两组的治疗有效率,并检测两组治疗前后的粪便SIgA含量。结果:联合用药的有效率明显高于单纯用药,治疗后两组粪便SIgA与治疗前比较有明显差异(P<0.05),治疗后对照组与试验组差异有统计学意义(P<0.05)。结论:苍苓止泻口服液联合思密达对轮状病毒肠炎患儿治疗临床效果显著,此联合药物可能是通过刺激肠道SIgA的分泌,改善肠道的免疫功能来发挥药效的。
Objective: To investigate the effect of Cangling Zhixie oral solution combined with Smecta on the intestinal immunity in children with rotavirus enteritis. Methods: A total of 200 children with rotavirus were randomly selected and treated with Cangling Zhixie Oral Liquid and Smecta in combination with 100 cases. Only 100 cases were treated with Smecta. The therapeutic efficacies of the two groups were calculated. Before and after treatment SIgA content of feces. Results: The effective rate of combination therapy was significantly higher than that of simple therapy. The SIgA of feces was significantly different between the two groups after treatment (P <0.05). There was significant difference between the control group and experimental group after treatment (P <0.05). Conclusion: The clinical effect of Cangling Zhixie oral solution combined with Smecta on children with rotavirus enteritis is significant. The combination drug may exert its efficacy by stimulating intestinal SIgA secretion and improving intestinal immune function.