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目的:探讨米非司酮配伍米索前列醇不同给药方法治疗稽留流产的临床效果。方法:将符合条件的396例患者随机分为2组:A组(胚胎停育≥10周)单次口服米非司酮150mg或200mg;B组(胚胎停育≥10周)早服米非司酮50mg,晚服25mg或50mg,连服2天。所有患者第3天顿服米索前列腺醇600μg,3h后根据病情再加量,观察两组不同停育周数的流产效果。结果:①A组有效率94.12%,完全流产率80.88%;B组有效率89.58%,完全流产率82.29%,两组比较无统计学差异(P>0.05)。②A+B组总有效率为91.92%,完全流产率为81.57%。③不同停育周数的有效率:<7周88.37%,7～10周92.59%,10～14周91.28%,>14周98.55%;完全流产率:<7周76.74%,7～10周79.26%,10～14周82.55%,>14周89.85%。结论:①米非司酮配伍米索前列醇治疗稽留流产具有成功率高、不良反应轻、并发症少等优点。②米非司酮单次服药法与多次服药法的疗效相当,但单次服药方法简单、方便、易行。③随着胚胎停育周数增大,稽留流产药流成功率有增高趋势。
Objective: To investigate the clinical effect of different administration of mifepristone and misoprostol on missed abortion. Methods: 396 eligible patients were randomly divided into two groups: group A (ovulation ≥10 weeks) received single oral mifepristone 150 mg or 200 mg; group B (embryo suspension ≥10 weeks) Secretary ketones 50mg, evening service 25mg or 50mg, and even served 2 days. All patients on the 3rd day dose of misoprostol 600ug, 3h after the disease according to the amount of observation of two groups of different weeks of abortion effect. Results: ① The effective rate of group A was 94.12% and the rate of complete abortion was 80.88%. The effective rate of group B was 89.58% and the rate of complete abortion was 82.29%. There was no significant difference between the two groups (P> 0.05). ② The total effective rate of A + B group was 91.92%, the complete abortion rate was 81.57%. (3) The effective rate of different weeks of sterilization was 88.37% in 7 weeks, 92.59% in 7-10 weeks, 91.28% in 10-14 weeks and 98.55% in 14 weeks. The complete abortion rate was 76.74% in 7 weeks, 7-10 weeks 79.26%, 82.55% in 10 ~ 14 weeks, 89.85% in> 14 weeks. Conclusion: ① mifepristone with misoprostol in the treatment of missed abortion has the advantages of high success rate, mild adverse reactions, fewer complications. ② mifepristone single medication and multiple medication efficacy is quite, but a single medication is simple, convenient and easy. ③ With the number of weeks of embryo suspension increases, the success rate of missed abortion drug flow has increased.