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降钙素基因相关肽(calcitonin generelated peptide,简称CGRP)是一组新近发现的、广泛分布于人和动物中的调节性神经肽,其不仅存在于中枢和周围神经系统中,而且也存在于心脏和血管中。迄今的人体和动物试验显示,CGRP具有正性肌力作用和扩血管作用。本文研究静注人α-CGRP对重度充血性心力衰竭(CHF)病人的血流动力学和血浆激素浓度的影响。方法 8例CHF病人(NYHAⅢ～Ⅳ级),在口服末次心脏药物6小时后,先行有关基础血流动力学参数和激素测定,随后用灌注泵从前臂静脉注射人α-CGRP,剂量依次为每分钟0.8、3.2和16 ng/kg,前两者剂
Calcitonin gene related peptide (CGRP) is a newly discovered group of regulatory neuropeptides that are widely found in humans and animals. They are not only found in the central and peripheral nervous system, but also in the heart And in the blood vessels. Human and animal experiments to date show that CGRP has positive inotropic and vasodilating effects. This article investigates the effects of intravenous alpha-CGRP on hemodynamics and plasma hormone concentrations in patients with severe congestive heart failure (CHF). Methods Eight patients with NYHA Ⅲ ~ Ⅳ were enrolled in this study. After 6 hours of oral administration of the last cardiac drug, baseline hemodynamic parameters and hormones were measured before injection of human α-CGRP from the forearm vein using a perfusion pump. The doses were Minutes 0.8, 3.2 and 16 ng / kg, the former two agents