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目的探讨枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停(apnea of prematurity,AOP)的有效性及安全性。方法 AOP患儿80例随机分为2组,观察组40例给予枸橼酸咖啡因治疗,对照组40例给予氨茶碱治疗。比较2组治疗有效率及不良反应发生情况。结果观察组治疗有效率(82.5%)与对照组(70.0%)比较差异无统计学意义(P>0.05);观察组心动过速(5.0%)、喂养不耐受(10.0%)、高血糖(7.5%)及支气管肺发育不良发生率(5.0%)低于对照组(22.5%、27.5%、25.0%、20.0%)(P<0.05),早产儿视网膜病变发生率(5.0%)与对照组(7.5%)比较差异无统计学意义(P>0.05)。结论枸橼酸咖啡因治疗AOP疗效与氨茶碱相似,但不良反应发生率较低。
Objective To investigate the efficacy and safety of citrate caffeine and aminophylline in the treatment of apnea of prematurity (AOP). Methods Eighty children with AOP were randomly divided into two groups. Forty patients in observation group were treated with citrulline citrate, while 40 in control group were treated with aminophylline. Compare the two groups of treatment efficiency and adverse reactions. Results There was no significant difference between the observation group (82.5%) and control group (70.0%) (P> 0.05). The observation group had tachycardia (5.0%), feeding intolerance (7.5%) and the incidence of bronchopulmonary dysplasia (5.0%) were lower than those in the control group (22.5%, 27.5%, 25.0% and 20.0%, P <0.05) Group (7.5%) was no significant difference (P> 0.05). Conclusion The efficacy of citrate caffeine in the treatment of AOP is similar to aminophylline, but the incidence of adverse reactions is low.