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表皮细胞生长因子(EGF)是一个强有力的促细胞分裂因子,已从多种哺乳动物中被分离和纯化.以小鼠EGF(mEGF)和人EGF(hEGF)为研究代表,对EGF的理化特性和生物学效应作了深入的研究。EGF能刺激活体内或体外培养的多种组织和细胞类型的分裂、增殖或分化。因此,EGF是生物学效应相当广泛的一种生长因子,并非仅作用于表皮组织。它也反映了EGF及其受体在生物进化上的保守性以及它对高等生物进化发育上的重要性。EGF不仅可以作为研究细胞相互作用的信息交流的代表物,而且由于近几年来发现EGF受体具有酪氨酸磷酸化蛋白激酶活性并与多种其它的生长因子、癌基因、促癌物的
Epidermal growth factor (EGF) is a potent mitogenic factor that has been isolated and purified from a variety of mammalian species and is characterized by the studies of mouse EGF (EGF) and human EGF (hEGF) Characteristics and biological effects made in-depth study. EGF can stimulate the division, proliferation or differentiation of many tissues and cell types cultured in vivo or in vitro. Therefore, EGF is a relatively broad biological effect of a growth factor, not only on the epidermal tissue. It also reflects the biological evolutionary conservation of EGF and its receptors and its importance for the evolutionary development of higher organisms. EGF can not only be used as a representative for the exchange of information on cell-cell interactions, but also because EGF receptors have been found to have tyrosine phosphorylation protein kinase activity in recent years and bind to various other growth factors, oncogenes, carcinogens