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目的 :研究激光小剂量血卟啉及 OMA计算机系统在支气管肺癌荧光诊断的临床应用。方法 :以2 mg/kg剂量的血卟啉衍生物 ( HPD)对 3 7例患者进行荧光诊断 ,其中 2 2例为肿癌患者 ,1 5例为非肿瘤患者。以 OMA计算机系统记录和分析荧光光谱 ,数据经归一化处理。结果 :肿瘤患者的标本荧光强度 Itumor/Ino-mal总平均为 1 .2 4± 0 .0 8,非肿瘤患者的标本荧光强度 Itumor/Inomal总平均为 0 .98± 0 .0 6,两组 t检验显示 p<0 .0 1 ,有非常显著的差异 ,以前者下限 1 .0 5为诊断肿瘤标准 ,2 2例恶性肿瘤患者的检测值全部符合标准 ,1 5例非恶性肿瘤患者中除 2例鳞状化生比值高于标准为假阳性外 ,其余均符合标准 ,据此诊断准确率为94 .6%。结论 :2 mg/kg小剂量血卟啉可作肿瘤荧光诊断。
Objective: To study the clinical application of laser small dose hematoporphyrin and OMA computer system in fluorescence diagnosis of bronchial carcinoma. Methods: Thirty-seven patients were diagnosed by hematoporphyrin derivative (HPD) at a dose of 2 mg / kg, of which 22 were tumor patients and 15 were non-tumor patients. Fluorescence spectra were recorded and analyzed by OMA computer system and the data were normalized. Results: The total fluorescence intensity of Itumor / Ino-mal in patients with tumors was 1.24 ± 0.08, and the total fluorescence intensity of Itumor / Inomal in patients with non-tumor was 0.98 ± 0.60 t test showed that p <0.01, there is a very significant difference, the former lower limit of 1.05 for the diagnosis of tumor standards, 2 2 cases of malignant tumor patients all meet the standard test, 15 cases of non-malignant tumor patients 2 cases of squamous metaplasia than the standard false positive, the rest are in line with the standard, the diagnostic accuracy of 94.6%. Conclusion: 2 mg / kg small dose of hematoporphyrin can be used for tumor fluorescence diagnosis.