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目的 :探讨盐藻β-胡萝卜素 (β- carotene,β- c)红细胞免疫粘附肿瘤细胞能力的影响。方法 :采用红细胞C3b受体花环试验和肿瘤细胞花环试验 ,检测了 36例正常人和 42例肿瘤病人红细胞 C3b受体花环率 (E-C3b RRR)和肿瘤红细胞花环率 (TERR) ,及不同浓度 β- c对 E- C3b RRR和 TERR的影响。结果 :肿瘤病人 E-C3b RRR和 TERR明显低于正常人 (P<0 .0 0 1 ) ,红细胞与不同浓度β- c温育后 ,正常人和肿瘤病人EC3b RRR和 TERR较温育前明显增高 ,差异有显著性 (P<0 .0 1 ,0 .0 0 1 ) ,当 β- c浓度为 5.0 0 %时 ,E-C3b RRR和 TERR最高。但肿瘤病人 E- C3RRR和 TERR仍低于正常人 (P<0 .0 0 1 )。结论 :β- c的抗肿瘤作用可能与其激活红细胞 C3b受体免疫粘附功能有关
Objective: To investigate the effect of β-carotene (β-c) red blood cell immune adherence on tumor cells. Methods: Erythrocyte C3b receptor rosette rate (E-C3b RRR) and tumor red blood cell rosette rate (TERR) were detected in 36 normal persons and 42 tumor patients using red blood cell C3b receptor rosette test and tumor cell rosette test. Effect of β-c on E-C3b RRR and TERR. RESULTS: E-C3b RRR and TER were significantly lower in cancer patients than in normal controls (P < 0.01). After incubation with red blood cells and different concentrations of beta-c, EC3b RRR and TER were significantly higher in normal and cancer patients than before incubation. The difference was significant (P<0.01, 0.01). When the β-c concentration was 5.00%, the E-C3b RRR and TERR were highest. However, the E-C3RRR and TERR in patients with cancer were still lower than those in normal subjects (P < 0.01). Conclusion: The anti-tumor effect of β-c may be related to its activation of red blood cell C3b receptor immunoadhesion function