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目的考察腹腔镜手术联合药物治疗子宫内膜异位症的临床效果。方法观察组1、观察组2及对照组各40例患者,均行腹腔镜手术治疗,其中观察组在术后分别给予米非司酮和孕三烯酮药物治疗,而对照组术后不给予任何药物治疗。结果观察组1、观察组2以及对照组的缓解率分别为77.5%、72.5%与52.5%,对应复发率为7.5%、7.5%与37.5%,两观察组比较缓解及复发率,差异均无统计学意义(P>0.05),而与对照组比较,差异均有统计学意义(P<0.05);观察组随访2年后的妊娠率分别为54.8%和51.9%,略高于对照组的47.1%,差异无统计学意义(P>0.05);观察组共有9例患者出现轻微肝酶升高的症状,但均未停止给药,在配合一定护肝治疗之后均逐渐恢复正常,其余不良反应还包括恶心、头痛、痤疮、体重增加以及不规则阴道流血等,但表现均很轻微,且在后续治疗过程中逐渐消退。结论腹腔镜联合米非司酮或孕三烯酮治疗子宫内膜异位症可让绝大部分患者症状消失或得以缓解,不良反应轻微可控,且复发率低,值得临床推广应用。
Objective To investigate the clinical effect of laparoscopic surgery combined with drug treatment of endometriosis. Methods Observation group 1, observation group 2 and control group of 40 patients were treated with laparoscopic surgery, the observation group were given mifepristone and gestrinone treatment, while the control group were not given postoperative Any medical treatment. Results The remission rates in observation group 1, observation group 2 and control group were 77.5%, 72.5% and 52.5% respectively, and the corresponding recurrence rates were 7.5%, 7.5% and 37.5% (P <0.05), while the difference was statistically significant (P <0.05) compared with the control group; the pregnancy rates of the observation group after two years of follow-up were 54.8% and 51.9%, respectively, slightly higher than that of the control group 47.1%, there was no significant difference between the two groups (P> 0.05). In the observation group, 9 patients showed mild symptoms of elevated liver enzymes, but did not stop the administration, and gradually returned to normal after treatment with certain liver protection. The reaction also includes nausea, headache, acne, weight gain and irregular vaginal bleeding, but the performance is very slight, and gradually subsided in the follow-up treatment. Conclusion Laparoscopy combined with mifepristone or gestrinone treatment of endometriosis can make the symptoms disappear or can be alleviated in most patients with mild side effects and control, and the recurrence rate is low, worthy of clinical application.