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近年来,国内外有人用皮肤涂擦(简称皮涂)左旋咪唑(LMS)来预防和治疗某些疾病,获得了良好的效果。据认为它可能成为预防动物丝虫感染的有效剂型及给药途径。本实验报道大鼠皮涂~3H-左旋咪唑后在体内的药代动力学变化,并与肌注的药代动力学进行比较。
In recent years, some people at home and abroad have rubbed the skin (referred to as skin coating) levamisole (LMS) to prevent and treat certain diseases, and achieved good results. It is believed that it may become an effective dosage form and route of administration to prevent animal filarial infections. In this study, we reported the pharmacokinetics of 3H-levamisole in rats and compared the pharmacokinetics with intramuscular injection.