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[目的]探讨阿维A胶囊对晚期非小细胞肺癌的诱导分化治疗的疗效。[方法]选择某院诊治的晚期非小细胞肺癌患者47例,根据随机原则分为观察组(24例)和对照组(23例)。观察组患者采用顺铂+阿维A胶囊方案,对照组患者仅应用顺铂方案,两组患者均坚持两个周期以上的化疗。比较两组患者治疗效果及不良反应发生情况,测量并比较治疗前后两组患者血癌胚抗原(CEA)、神经特异烯醇化酶(NSE)及非小细胞相关抗原(CYFRA21-1)水平。[结果]①观察组患者治疗有效率、疾病控制率高于对照组,但均无统计学意义(P﹥0.05)。②治疗后,观察组患者血CEA、NSE及CYFRA21-1水平明显低于治疗前(P﹤0.05)。对照组中,仅CYFRA21-1的水平有显著降低(P﹤0.05)。观察组患者血CEA及CYFRA21-1水平明显低于对照组(P﹤0.05)。③观察组与对照组不良反应的发生率间差异无统计学意义(P﹥0.05)。[结论]阿维A胶囊能够显著降低晚期非小细胞肺癌血清肿瘤标记物水平,并能在一定程度上提高疗效。
[Objective] To investigate the therapeutic effect of Avia A capsule on differentiation and differentiation of advanced non-small cell lung cancer. [Methods] Forty-seven patients with advanced non-small cell lung cancer who were selected for treatment in a hospital were divided into observation group (24 cases) and control group (23 cases) according to the randomized principle. Observation group patients with cisplatin + Avi A capsule program, the control group only patients with cisplatin regimen, two groups of patients were insisted on more than two cycles of chemotherapy. The therapeutic effects and adverse reactions of the two groups were compared. The levels of CEA, NSE and CYFRA21-1 in both groups were measured and compared before and after treatment. [Results] ① The effective rate of treatment and the rate of disease control in observation group were higher than those in control group, but there was no statistical significance (P> 0.05). ② After treatment, the levels of CEA, NSE and CYFRA21-1 in the observation group were significantly lower than those before treatment (P <0.05). In the control group, only the level of CYFRA21-1 was significantly reduced (P <0.05). The levels of CEA and CYFRA21-1 in the observation group were significantly lower than those in the control group (P <0.05). ③ There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P> 0.05). [Conclusion] Avia A capsule can significantly reduce the level of serum tumor markers in advanced non-small cell lung cancer, and can improve the curative effect to a certain extent.