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文章简介移植胚胎来源的中间神经元(又称:抑制性神经元)在对神经病理学以及精神疾病的研究中,已经展现出了改善疾病症状的现象。然而,移植中间神经元是否可以调制恐惧记忆,目前还不清楚。在这里,本研究将报道移植胚胎来源的中间神经元到杏仁核中并不改变恐惧记忆的形成,但是不在更早或更晚的时间点,而是大约在移植2周后,对小鼠进行恐惧记忆的消除训练,小鼠的恐惧记忆的自发恢复以及恐惧记忆的重现有明显降低。
INTRODUCTION Transplantation of embryonic-derived interneurons (also known as inhibitory neurons) has shown to ameliorate symptoms of disease in neuropathology and psychiatric disorders. However, it is unclear whether transplanted interneurons can modulate fear memory. Here, we report that transplanting embryo-derived interneurons into the amygdala does not alter the formation of fear memory but is not at an earlier or later time point, but rather about 2 weeks after transplantation, mice are treated The elimination of fear memory training, the spontaneous recovery of fear memory mice and the recurrence of fear memory have significantly reduced.