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目的研究EGFR、HER-2、TopoⅡα在胃癌组织中的表达与临床病理特征之间的关系。方法应用免疫组化方法检测108例胃癌及22例正常胃组织中EGFR、HER-2、TopoⅡα的表达情况,分析三者的表达与临床病理特征之间的关系,并对其相关性进行分析。结果 108例胃癌组织中EGFR、HER-2、TopoⅡα阳性表达率分别为41.7%、31.5%、53.7%,22例正常胃组织阳性表达率分别为和0%、0%、4.5%。EGFR、HER-2、TopoⅡα蛋白的高表达与胃癌的部位、细胞分化程度、浸润深度、淋巴结转移及TNM分期有关(P<0.05,P<0.01);而与患者的性别、年龄及肿瘤直径无明显关系(P>0.05)。EGFR与HER-2之间(r=0.317,P=0.001),EGFR与TopoⅡα之间(r=0.257,P=0.007),HER-2与TopoⅡα之间(r=0.270,P=0.005)的表达均呈正相关。结论 EGFR、HER-2、TopoⅡα在胃癌组织表达增高与胃癌的发生、发展密切相关。
Objective To study the relationship between the expression of EGFR, HER-2 and TopoⅡα in gastric carcinoma and the clinicopathological features. Methods The expressions of EGFR, HER-2 and TopoⅡα in 108 cases of gastric cancer and 22 cases of normal gastric tissue were detected by immunohistochemistry. The relationship between the three expressions and clinicopathological characteristics was analyzed and their correlations were analyzed. Results The positive rates of EGFR, HER-2 and TopoⅡα in 108 cases of gastric cancer tissues were 41.7%, 31.5% and 53.7% respectively. The positive expression rates of EGFR, HER-2 and TOPOⅡ in 22 cases of normal gastric tissues were 0%, 0% and 4.5%, respectively. The overexpression of EGFR, HER-2 and TopoⅡα was associated with the location of gastric cancer, cell differentiation, depth of invasion, lymph node metastasis and TNM stage (P <0.05, P <0.01), but not with the gender, age and tumor diameter Significant relationship (P> 0.05). Expression of EGFR and HER-2 (r = 0.317, P = 0.001), EGFR and TopoⅡα (r = 0.257, P = 0.007), HER-2 and TopoⅡα All were positively correlated. Conclusion The increased expression of EGFR, HER-2 and TopoⅡα in gastric cancer tissues is closely related to the occurrence and development of gastric cancer.