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尽管胺碘酮对治疗危及生命的室性心律失常是一种有效的药物,但口服的标准负荷量方案至今尚未确定,为了弄清胺碘酮的负荷量,患者常需延长住院时间。大剂量(>1,800mg/d)的口服负荷量,通常仅用于伴有频繁的室性快速性心律失常发作的不稳定患者。因而有必要研究:(1)大剂量口服胺碘酮负荷量对比较稳定患者的临床和电生理作用;(2)确定其安全性或耐受性,是否有可能缩短负荷期和减少住院时间。 16例过去有反复发作的室性心律失常
Although amiodarone is a potent drug for the treatment of life-threatening ventricular arrhythmias, the oral standard loading regimen has not been established so far, and patients often have to prolong their length of hospital stay to ascertain the amiodarone load. Large doses (> 1,800mg / d) of oral load, usually only for patients with frequent ventricular tachyarrhythmia in unstable patients. Therefore, it is necessary to study: (1) the clinical and electrophysiological effects of high-dose oral amiodarone loading in patients with relatively stable conditions; (2) to determine its safety or tolerability, whether it is possible to shorten the loading period and reduce the length of hospital stay. Sixteen patients had recurrent ventricular arrhythmias in the past