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目的:观察乳突根治术后应用重组人表皮生长因子对乳突腔上皮化的影响。方法:选择胆脂瘤中耳炎42例行开放式乳突根治术,术后应用重组人表皮生长因子凝胶及新可合剂处理乳突术腔20例(观察组);仅用新可合剂处理乳突术腔22例(对照组)。比较两组术腔愈合情况和上皮化时间。结果:观察组上皮化时间3～5周,平均(27.1±3.9)天;对照组上皮化时间4～7周,平均(30.3±2.6)天。两组比较,差异非常显著(P<0.01)。结论:重组人表皮生长因子可促进上皮组织增生,加速乳突腔上皮化,提高乳突根治术疗效。
Objective: To observe the effect of recombinant human epidermal growth factor on mastoid cavity epithelialization after radical mastectomy. Methods: 42 cases of cholesteatoma otitis media were treated with open mastoidectomy, and 20 cases of mastoid cavity were treated with recombinant human epidermal growth factor gel and Xinkeheji (observation group) Tricuspid surgery in 22 cases (control group). The healing status of the two groups and the time of epithelialization were compared. Results: In the observation group, the epithelialization time was 3 to 5 weeks with an average of (27.1 ± 3.9) days and that in the control group with an average of (30.3 ± 2.6) days from 4 to 7 weeks. The differences between the two groups were significant (P <0.01). Conclusion: Recombinant human epidermal growth factor can promote the proliferation of epithelial tissue, accelerate the mastoid cavity epithelialization and improve the curative effect of mastoidectomy.