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目的:研究超声内镜引导下细针穿刺活检(EUS-FNA)联合K-ras基因检测对胰腺癌的诊断价值,为临床诊疗提供依据。方法:选取2013年11月到2015年11月我院收治的胰腺占位病变患者90例,患者入院次日行EUS-FNA,检测患者血清及活检物中K-ras基因阳性率,比较EUS-FNA单独与EUS-FNA联合K-ras基因检测对胰腺癌诊断的准确率与敏感性。结果:90例胰腺占位病变者中,经病理证实胰腺癌56例,EUS-FNA单独与EUS-FNA联合K-ras基因分别检出胰腺癌50例、53例,准确率分别为89.29%、94.64%,敏感性分别为92.59%、98.15%,两组比较差异均有统计学意义(P<0.05)。胰腺癌患者活检物中K-ras阳性率为83.93%,明显高于血清中的41.07%(P<0.05)。结论:EUS-FNA联合K-ras基因检测可提高对胰腺癌诊断的准确率与敏感性。
Objective: To study the diagnostic value of EUS-FNA combined with K-ras gene in the diagnosis of pancreatic cancer under endoscopic ultrasonography and provide the basis for clinical diagnosis and treatment. Methods: Ninety patients with pancreatic mass lesions admitted to our hospital from November 2013 to November 2015 were enrolled. EUS-FNA was performed on the next day after admission. The positive rates of K-ras gene in serum and biopsy specimens were detected. Accuracy and Sensitivity of FNA Combined with EUS-FNA and K-ras Gene Detection in Diagnosis of Pancreatic Cancer. Results: Among the 90 cases of pancreatic lesions, 56 cases of pancreatic cancer confirmed by pathology, 50 cases of pancreatic cancer were detected by EUS-FNA alone and KUS-FNA combined with K-ras gene, 53 cases were diagnosed as pancreatic cancer with the accuracy rate of 89.29% 94.64% respectively. The sensitivity was 92.59% and 98.15% respectively. There was significant difference between the two groups (P <0.05). The positive rate of K-ras in pancreatic cancer biopsy specimens was 83.93%, which was significantly higher than 41.07% in serum (P <0.05). Conclusion: The combination of EUS-FNA and K-ras gene detection can improve the diagnostic accuracy and sensitivity of pancreatic cancer.