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通过参与合成和转运核苷及其类似物,人体中的平衡型核苷转运蛋白在生物体内参与了细胞发育、能量代谢和信号转导等众多生理生化过程,其研究对于癌症、病毒感染等相关疾病的治疗有着极为重要的意义。该文综述了该类蛋白质在人体内的发现历程、分类、结构和作用机制,并对于其在一些疾病治疗和药物开发方面的前景进行了展望。
By participating in the synthesis and translocation of nucleosides and their analogues, the human balanced nucleoside transport protein is involved in a number of physiological and biochemical processes such as cell development, energy metabolism and signal transduction in vivo, and its research is related to cancer and viral infection The treatment of diseases is of great importance. This review summarizes the discovery, classification, structure and mechanism of action of this class of proteins in human and prospects the prospects for some diseases treatment and drug development.