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目的： 观察三氯苯达唑在体内外杀灭卫氏并殖吸虫后， 虫体体壁及卵黄细胞超微结构的变化。方法：将被药物在体内、外杀死的虫体及对照组正常虫体， 按常规方法制成电镜样品， 用扫描和透射电镜观察。结果： 在药物作用下， 体壁的外质膜及基质层裂解消失， 肌肉层有不同程度的坏死， 皮层细胞膜及卵黄细胞膜破坏消失，核膜部份破坏， 核内异染色质凝固、聚边、直至溶解。胞质内的高尔基体消失， 内质网扩张， 线粒体肿胀变性、直至溶解，但对糖原颗粒无明显影响。对体内虫体的破坏比体外严重。结论： 三氯苯达唑对卫氏并殖吸虫的体壁及卵黄细胞均有明显的破坏作用， 主要破坏细胞核、细胞的膜质结构以及微管系统， 并可使虫体皮层裂解消失。
OBJECTIVE: To observe the changes of the ultrastructure of the body wall and the yolk cells of trichostrobin after the in vitro and in vivo killing of Paragonimus westermani. Methods: The normal parasites killed by the drug in vivo and in vitro and the control group were made into electron microscopy samples by conventional methods and observed by scanning and transmission electron microscopy. Results: Under the action of the drug, the outer wall of the body wall lysis and disappearance of the outer plasma membrane and stroma, the muscle layer with varying degrees of necrosis, cortical membrane and villus cell membrane damage disappeared, partial destruction of the nuclear membrane, nuclear heterochromatin coagulation, poly edge Until dissolved. The cytoplasm of the Golgi disappeared, the endoplasmic reticulum dilated, mitochondria swelling until the dissolution, but no significant effect on glycogen particles. Damage to body parasites than in vitro serious. CONCLUSION: Triclabendazole can significantly damage the body wall and yolk cells of Paragonimus westermani, which mainly destroy the cell nucleus, membranous structure and microtubule system of the Paragonimus.