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Background:disease(BD)is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective:The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and methods:Seventeen patients with BD within a pediatric age group were studied since 1997.Results:Boys :girls ratio was 12:5.Familial cases were very frequent(45%).Oral aphthous ulcers were presentin all patients(100%),genital aphthous ulcers were present in 16(94%),ocular lesions in 4(24%),erythema nodosum in 3(18%),papulopustules in 8(47%),joint symptoms in 13(76%),mild gastrointestinal symptoms in 2(12%),neurological involvement in 2(12%),positive pathergy reactions in 13(76%),and thrombophlebitis in 1(6%).We used colchicine,system iccorticosteroids,cyclosporine,nonsteroidal anti-inflammatory drugs,sulfasalazine,and topical agents for the treatment of children with BD.Conclusion:The findings of BD in children are similar as in adults,but the frequency of familial cases is significantly higher.
Background: disease (BD) is a systemic inflammatory vasculitis of young adults with unknown etiology. Objective: The aim of this study was to determine the clinical features and outcome of BD in childhood. Pats and methods: Seventeen patients with BD within a pediatric age group were studied since 1997. Results: Boys: girls ratio was 12: 5.Familial cases were very frequent (45%). Oral aphthous ulcers were presentin all patients (100%), genital aphthous ulcers were present in 16 , ocular lesions in 4 (24%), erythema nodosum in 3 (18%), papulopustules in 8 (47%), joint symptoms in 13 (12%), positive pathergy reactions in 13 (76%), and thrombophlebitis in 1 (6%). We used colchicine, system iccorticosteroids, cyclosporine, nonsteroidal anti-inflammatory drugs, sulfasalazine, and topical agents for the treatment of children with BD.Conclusion: The findings of BD in children are similar as in adults, but the frequency of familial cases is sig nificantly