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目的探讨复方丹参液对大鼠失血性休克合并凝血功能紊乱的影响。方法将40只SD大鼠随机分为假手术组10只、休克组10只、复方丹参液组10只及肝素组10只四个组,对检测结果进行比较。结果大鼠休克组与假手术组、复方丹参液组及肝素组的血浆SFMC水平相比差异有统计学意义(P<0.05),大鼠休克组与假手术组、复方丹参液组及肝素组的ATⅢ相比差异无统计学意义(P>0.05)。休克组、肝素组与复方丹参组、假手术组的血浆TM水平相差异有统计学意义(P<0.05)。结论复方丹参液优势显著,主要表现在安全好、出血少、疗效快。
Objective To investigate the effect of compound Danshen solution on hemorrhagic shock with coagulation disorder in rats. Methods Forty Sprague-Dawley rats were randomly divided into sham operation group (n = 10), shock group (n = 10), Fufang Danshen solution group (n = 10) and heparin group (n = 10). Results Compared with the sham group, Fufang Danshen liquid group and heparin group, the plasma SFMC levels in the shock group were significantly different (P <0.05), the shock group and the sham operation group, the compound Danshen liquid group and the heparin group There was no significant difference in AT Ⅲ (P> 0.05). There was significant difference in plasma TM level between shock group, heparin group and compound Danshen group and sham operation group (P <0.05). Conclusion Danshen liquid has significant advantages, mainly in safety, less bleeding, fast response.