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目的了解甲型H1N1流感大流行后开封市不同时期、不同地区、不同人群甲型H1N1流感血清抗体水平,以掌握甲型H1N1流感抗体水平和发展趋势,为预防控制工作提供指导。方法采用3个阶段随机抽样,分别抽取不同年龄组(0~5、6~15、16~24、25~59、60岁及以上)222、230和199人,采用血凝抑制方法对标本进行甲型H1N1流感抗体检测,并运用SAS软件对反馈的检测结果进行统计分析。结果 3次检测甲型H1N1流感抗体阳性率分别为11.26%、12.17%和26.13%,差异有统计学意义(χ2=21.26,P<0.01);城乡和性别差异均无统计学意义(P>0.05);第1次检测抗体阳性率年龄差异有统计学意义(χ2=12.88,P=0.01),第2和第3次检测差异均无统计学意义。结论开封市普通人群甲型H1N1流感抗体水平逐步升高,但是抗体水平普遍偏低,未达到免疫保护的水平,16~24岁年龄组抗体阳性率最高(22.73%)。
Objective To understand the serum antibody level of Influenza A (H1N1) in different periods, different regions and different populations after the Influenza A (H1N1) influenza pandemic in Kaifeng city in order to master the antibody level and development trend of Influenza A (H1N1) and provide guidance for prevention and control. Methods A total of 222, 230 and 199 patients of different age groups (0 ~ 5,6 ~ 15,16 ~ 24,25 ~ 59,60 and above) were enrolled in this study. The samples were obtained by hemagglutination inhibition Influenza A H1N1 influenza antibody testing, and the use of SAS software on the feedback test results for statistical analysis. Results The positive rates of influenza A (H1N1) antibody in the three tests were 11.26%, 12.17% and 26.13%, respectively, with statistical significance (χ2 = 21.26, P <0.01). There was no significant difference between urban and rural areas (P> 0.05) ). The positive rate of the first test antibody was statistically significant (χ2 = 12.88, P = 0.01). There was no significant difference between the second test and the third test. Conclusions The level of antibody against influenza A (H1N1) in the general population of Kaifeng City gradually increased. However, antibody levels were generally low and did not reach the level of immunoprotection. The highest positive rate was found in the age group of 16-24 years old (22.73%).