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用无细胞菌苗初次免疫的婴儿,这些儿童再用百日咳无细胞菌苗加强免疫,有关效果的资料很少。在19月龄时,作者用百日咳无细胞菌苗加强免疫,41名婴儿随机分成2组,在2、4、6月龄时,1组接受无细胞菌苗(ACV),另1组接受全菌体菌苗(WCV),在7月龄时,ACV组比WCV组产生较高效价的抗百日咳毒素的抗体和丝状血凝素。在15个月龄时,接受百日咳ACV组,抗丝状血凝素的抗体(不是百日咳毒素)仍保持较高的水
In infants immunized with acellular bacterins, these children were boosted with aseptic acellular bacterin and little information was available about the effect. At 19 months of age, the authors boosted with acellular pertussis vaccine and 41 infants were randomized into 2 groups. At 2, 4, and 6 months of age, group 1 received a cell-free vaccine (ACV) and the other group received full Bacterial mycobacteria (WCV), at 7 months of age, the ACV group produced higher titers of pertussis toxin antibodies and filamentous hemagglutinin than the WCV group. At 15 months of age, the antibody to pertussis ACV, anti-fibrinogen (not pertussis toxin) remained high in water