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晚近报告,低蛋白饮食疗法能有效地阻止糖尿病肾病的进展,但低蛋白饮食可能促使低营养状态和必需氨基酸减少,似有值得改进之处。本研究为探讨在糖尿病肾病实施低蛋白饮食疗法时期,放宽限制蛋白的可能性,观察多种蛋白急性负荷时的肾功能改变。病人和方法以健康人10名和糖尿病患者6例为研究对象,后者均为正常白蛋白尿(20μg/min)。受检者检查前一日晚上8时后禁食,翌晨8时排尿弃去,饮水400ml,于1小时后给予0.7g/kg 蛋白负荷,并佐以饮水100ml,以后每小时给水100ml。从检查开始时每小时测肾小球滤过率(GFR)和尿白蛋白排泄率(AER),并于负荷前后测血中氨基酸浓度。负
It has been recently reported that low-protein diet therapy can effectively prevent the progression of diabetic nephropathy, but low-protein diet may promote low nutritional status and reduced essential amino acids, there may be room for improvement. This study was designed to explore the possibility of relaxing the restriction protein in diabetic nephropathy during the low protein dietary therapy and to observe the changes of renal function in the acute load of various proteins. Patients and methods were 10 healthy subjects and 6 diabetic patients, all of whom had normal albuminuria (20μg / min). The subjects checked fasting after 8 o’clock on the day before the morning, urinated and discarded at 8 o’clock the next morning, drinking water 400ml, given 0.7g / kg protein load after 1 hour, supplemented with 100ml of drinking water, then water 100ml per hour. Glomerular filtration rate (GFR) and urinary albumin excretion rate (AER) were measured hourly from the beginning of the test, and amino acid concentrations were measured before and after loading. negative